diff --git a/Misc/NEWS.d/next/Build/2026-08-14-20-16-55.gh-issue-153400.9Oxi-N.rst b/Misc/NEWS.d/next/Build/2026-08-14-20-16-55.gh-issue-153400.9Oxi-N.rst
new file mode 100644
index 000000000000000..38eb51fa311562f
--- /dev/null
+++ b/Misc/NEWS.d/next/Build/2026-08-14-20-16-55.gh-issue-153400.9Oxi-N.rst
@@ -0,0 +1 @@
+Fall back to the kernel-provided __NR_getrandom in configure checks, os.getrandom(), and interpreter entropy handling when libc SYS_getrandom is not available.
diff --git a/Modules/posixmodule.c b/Modules/posixmodule.c
index d94291e2ae524bc..7838dd5497e3e5a 100644
--- a/Modules/posixmodule.c
+++ b/Modules/posixmodule.c
@@ -160,6 +160,9 @@
 #ifdef HAVE_SYS_SYSCALL_H
 #  include <sys/syscall.h>        // syscall(), __NR_xxx syscall numbers
 #endif
+#if !defined(SYS_getrandom) && defined(__NR_getrandom)
+#  define SYS_getrandom __NR_getrandom
+#endif
 
 #ifdef HAVE_POSIX_SPAWN
 #  include <spawn.h>              // posix_spawn()
diff --git a/Python/bootstrap_hash.c b/Python/bootstrap_hash.c
index 5bc45d503360376..a22688827612657 100644
--- a/Python/bootstrap_hash.c
+++ b/Python/bootstrap_hash.c
@@ -23,7 +23,10 @@
 #    include <sys/random.h>       // getrandom()
 #  endif
 #  if !defined(HAVE_GETRANDOM) && defined(HAVE_GETRANDOM_SYSCALL)
-#    include <sys/syscall.h>      // SYS_getrandom
+#    include <sys/syscall.h>      // __NR_getrandom, SYS_getrandom
+#    if !defined(SYS_getrandom) && defined(__NR_getrandom)
+#      define SYS_getrandom __NR_getrandom
+#    endif
 #  endif
 #endif
 
diff --git a/configure b/configure
index ea560d600722592..af3d65cac1b35f8 100755
--- a/configure
+++ b/configure
@@ -34261,7 +34261,11 @@ cat confdefs.h - <<_ACEOF >conftest.$ac_ext
     #include <stddef.h>
     #include <unistd.h>
     #include <sys/syscall.h>
-    #include <linux/random.h>
+    #include <linux/random.h>  // GRND_NONBLOCK
+
+    #if !defined(SYS_getrandom) && defined(__NR_getrandom)
+    #  define SYS_getrandom __NR_getrandom
+    #endif
 
     int main(void) {
         char buffer[1];
diff --git a/configure.ac b/configure.ac
index 7dfc6ca29297a8b..6c6dc9c75fe1ad6 100644
--- a/configure.ac
+++ b/configure.ac
@@ -7872,7 +7872,11 @@ AC_LINK_IFELSE(
     #include <stddef.h>
     #include <unistd.h>
     #include <sys/syscall.h>
-    #include <linux/random.h>
+    #include <linux/random.h>  // GRND_NONBLOCK
+
+    #if !defined(SYS_getrandom) && defined(__NR_getrandom)
+    #  define SYS_getrandom __NR_getrandom
+    #endif
 
     int main(void) {
         char buffer[1];